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KMID : 1098420080160030192
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 3 p.192 ~ p.194
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Inhibitory Effect of White Ginseng Fraction on Skin Pigmentation
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Jo Youn-Ock
Choi Sang-Yoon
Kim Sung-Soo
Kong Yeon-Hee
Lee Young-Chul
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Abstract
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In our previous study, ethylacetate fraction of white ginseng (root of Panax ginseng C.A. Meyer) extract inhibited mushroom tyrosinase activity and melanin production in melanocytes. This study examined its effects on the expression of melanin biosynthesis-related enzymes to explore the depigmenting pathway. Moreover, depigmenting effect on animal skin was examined using UV-B induced hyperpigmented skin of brown guinea pigs. The ethylacetate fraction of the white ginseng extract exhibited depigmenting activity in the skin of brown guinea pig without visible edema. In addition, this fraction reduced tyrosinase expression in melanocytes. The results suggested that ethylacetate fraction of white ginseng extract might be used as skin depigmenting material by inhibition of tyrosinase activity and expression.
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KEYWORD
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Ginseng, Melanin, Pigment
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